Migraine patients present increased risks of vascular diseases such as high blood pressure, insulin resistance, metabolic syndrome, stroke and coronary heart disease. Oxidative stress (OS) is increasingly being studied in relation to the pathophysiology of migraine, stimulated by the described association with the most frequent migraine comorbidities. Because many of the gene-encoded players of the OS balance are characterized by functional polymorphisms, it is supposed that the individual genomic profile could affect susceptibility to OS and to related pathophysiological conditions. This study aimed to characterize a panel of 10 polymorphisms in 8 OS-related genes in a chronic migraine (CM) population and healthy controls, to recognize a genetic risk in the process of migraine chronification. The sample consisted of 45 healthy women and 96 women diagnosed with CM. No deviations from the Hardy-Weinberg equilibrium were detected, or in the overall population, or in the CM group or in the control group.

Lack of association between oxidative stress-related gene polymorphisms and chronic migraine in an Italian population / Gentile, Giovanna; Negro, Andrea; D'Alonzo, L; Aimati, L; Simmaco, Maurizio; Martelletti, Paolo; Borro, Marina. - In: EXPERT REVIEW NEUROTHERAPEUTICS. - ISSN 1744-8360. - ELETTRONICO. - 15:2(2015), pp. 215-225. [10.1586/14737175.2015.1001748]

Lack of association between oxidative stress-related gene polymorphisms and chronic migraine in an Italian population

GENTILE, Giovanna;NEGRO, ANDREA
Co-primo
Writing – Original Draft Preparation
;
SIMMACO, Maurizio;MARTELLETTI, Paolo;BORRO, Marina
2015

Abstract

Migraine patients present increased risks of vascular diseases such as high blood pressure, insulin resistance, metabolic syndrome, stroke and coronary heart disease. Oxidative stress (OS) is increasingly being studied in relation to the pathophysiology of migraine, stimulated by the described association with the most frequent migraine comorbidities. Because many of the gene-encoded players of the OS balance are characterized by functional polymorphisms, it is supposed that the individual genomic profile could affect susceptibility to OS and to related pathophysiological conditions. This study aimed to characterize a panel of 10 polymorphisms in 8 OS-related genes in a chronic migraine (CM) population and healthy controls, to recognize a genetic risk in the process of migraine chronification. The sample consisted of 45 healthy women and 96 women diagnosed with CM. No deviations from the Hardy-Weinberg equilibrium were detected, or in the overall population, or in the CM group or in the control group.
2015
chronic migraine; gene polymorphisms; oxidative stress
01 Pubblicazione su rivista::01a Articolo in rivista
Lack of association between oxidative stress-related gene polymorphisms and chronic migraine in an Italian population / Gentile, Giovanna; Negro, Andrea; D'Alonzo, L; Aimati, L; Simmaco, Maurizio; Martelletti, Paolo; Borro, Marina. - In: EXPERT REVIEW NEUROTHERAPEUTICS. - ISSN 1744-8360. - ELETTRONICO. - 15:2(2015), pp. 215-225. [10.1586/14737175.2015.1001748]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/781942
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